Sequence divergence of measles virus haemagglutinin during natural evolution and adaptation to cell culture.
Identifieur interne : 000695 ( Main/Exploration ); précédent : 000694; suivant : 000696Sequence divergence of measles virus haemagglutinin during natural evolution and adaptation to cell culture.
Auteurs : B K Rima [Royaume-Uni] ; J A Earle ; K. Baczko ; V. Ter Meulen ; U G Liebert ; C. Carstens ; J. Caraba A ; M. Caballero ; M L Celma ; R. Fernandez-Mu OzSource :
- The Journal of general virology [ 0022-1317 ] ; 1997.
Descripteurs français
- KwdFr :
- Amorces ADN (MeSH), Animaux (MeSH), Callithrix (MeSH), Cellules Vero (MeSH), Cellules géantes (MeSH), Espagne (MeSH), Humains (MeSH), Hémagglutinines virales (composition chimique), Hémagglutinines virales (génétique), Lignée cellulaire (MeSH), Lymphocytes B (MeSH), Mutation ponctuelle (MeSH), Phylogenèse (MeSH), Rougeole (virologie), Réaction de polymérisation en chaîne (MeSH), Réplication virale (MeSH), Sélection génétique (MeSH), Séquence nucléotidique (MeSH), Variation génétique (MeSH), Virus de la rougeole (classification), Virus de la rougeole (génétique), Virus de la rougeole (physiologie).
- MESH :
- composition chimique : Hémagglutinines virales, Virus de la rougeole.
- génétique : Hémagglutinines virales, Virus de la rougeole.
- physiologie : Virus de la rougeole.
- virologie : Rougeole.
- Amorces ADN, Animaux, Callithrix, Cellules Vero, Cellules géantes, Espagne, Humains, Lignée cellulaire, Lymphocytes B, Mutation ponctuelle, Phylogenèse, Réaction de polymérisation en chaîne, Réplication virale, Sélection génétique, Séquence nucléotidique, Variation génétique.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Animals (MeSH), B-Lymphocytes (MeSH), Base Sequence (MeSH), Callithrix (MeSH), Cell Line (MeSH), Chlorocebus aethiops (MeSH), DNA Primers (MeSH), Genetic Variation (MeSH), Giant Cells (MeSH), Hemagglutinins, Viral (chemistry), Hemagglutinins, Viral (genetics), Humans (MeSH), Measles (virology), Measles virus (classification), Measles virus (genetics), Measles virus (physiology), Phylogeny (MeSH), Point Mutation (MeSH), Polymerase Chain Reaction (MeSH), Selection, Genetic (MeSH), Spain (MeSH), Vero Cells (MeSH), Virus Replication (MeSH).
- MESH :
- chemical , chemistry : Hemagglutinins, Viral.
- chemical , genetics : Hemagglutinins, Viral.
- chemical : DNA Primers.
- geographic : Spain.
- classification : Measles virus.
- genetics : Measles virus.
- physiology : Measles virus.
- virology : Measles.
- Animals, B-Lymphocytes, Base Sequence, Callithrix, Cell Line, Chlorocebus aethiops, Genetic Variation, Giant Cells, Humans, Phylogeny, Point Mutation, Polymerase Chain Reaction, Selection, Genetic, Vero Cells, Virus Replication.
Abstract
Phylogenetic analysis of the sequence of the H gene of 75 measles virus (MV) strains (32 published and 43 new sequences) was carried out. The lineage groups described from comparison of the nucleotide sequences encoding the C-terminal regions of the N protein of MV were the same as those derived from the H gene sequences in almost all cases. The databases document a number of distinct genotype switches that have occurred in Madrid (Spain). Well-documented is the complete replacement of lineage group C2, the common European genotype at that time, with that of group D3 around the autumn of 1993. No further isolations of group C2 took place in Madrid after this time. The rate of mutation of the H gene sequences of MV genotype D3 circulating in Madrid from 1993 to 1996 was very low (5 x 10(-4) per annum for a given nucleotide position). This is an order of magnitude lower than the rates of mutation observed in the HN genes of human influenza A viruses. The ratio of expressed over silent mutations indicated that the divergence was not driven by immune selection in this gene. Variations in amino acid 117 of the H protein (F or L) may be related to the ability of some strains to haemagglutinate only in the presence of salt. Adaptation of MV to different primate cell types was associated with very small numbers of mutations in the H gene. The changes could not be predicted when virus previously grown in human B cell lines was adapted to monkey Vero cells. In contrast, rodent brain-adapted viruses displayed a lot of amino acid sequence variation from normal MV strains. There was no convincing evidence for recombination between MV genotypes.
DOI: 10.1099/0022-1317-78-1-97
PubMed: 9010291
Affiliations:
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Baczko</name></author><author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V" last="Ter Meulen">V. Ter Meulen</name></author><author><name sortKey="Liebert, U G" sort="Liebert, U G" uniqKey="Liebert U" first="U G" last="Liebert">U G Liebert</name></author><author><name sortKey="Carstens, C" sort="Carstens, C" uniqKey="Carstens C" first="C" last="Carstens">C. Carstens</name></author><author><name sortKey="Caraba A, J" sort="Caraba A, J" uniqKey="Caraba A J" first="J" last="Caraba A">J. Caraba A</name></author><author><name sortKey="Caballero, M" sort="Caballero, M" uniqKey="Caballero M" first="M" last="Caballero">M. Caballero</name></author><author><name sortKey="Celma, M L" sort="Celma, M L" uniqKey="Celma M" first="M L" last="Celma">M L Celma</name></author><author><name sortKey="Fernandez Mu Oz, R" sort="Fernandez Mu Oz, R" uniqKey="Fernandez Mu Oz R" first="R" last="Fernandez-Mu Oz">R. Fernandez-Mu Oz</name></author></analytic><series><title level="j">The Journal of general virology</title><idno type="ISSN">0022-1317</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>B-Lymphocytes (MeSH)</term><term>Base Sequence (MeSH)</term><term>Callithrix (MeSH)</term><term>Cell Line (MeSH)</term><term>Chlorocebus aethiops (MeSH)</term><term>DNA Primers (MeSH)</term><term>Genetic Variation (MeSH)</term><term>Giant Cells (MeSH)</term><term>Hemagglutinins, Viral (chemistry)</term><term>Hemagglutinins, Viral (genetics)</term><term>Humans (MeSH)</term><term>Measles (virology)</term><term>Measles virus (classification)</term><term>Measles virus (genetics)</term><term>Measles virus (physiology)</term><term>Phylogeny (MeSH)</term><term>Point Mutation (MeSH)</term><term>Polymerase Chain Reaction (MeSH)</term><term>Selection, Genetic (MeSH)</term><term>Spain (MeSH)</term><term>Vero Cells (MeSH)</term><term>Virus Replication (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Amorces ADN (MeSH)</term><term>Animaux (MeSH)</term><term>Callithrix (MeSH)</term><term>Cellules Vero (MeSH)</term><term>Cellules géantes (MeSH)</term><term>Espagne (MeSH)</term><term>Humains (MeSH)</term><term>Hémagglutinines virales (composition chimique)</term><term>Hémagglutinines virales (génétique)</term><term>Lignée cellulaire (MeSH)</term><term>Lymphocytes B (MeSH)</term><term>Mutation ponctuelle (MeSH)</term><term>Phylogenèse (MeSH)</term><term>Rougeole (virologie)</term><term>Réaction de polymérisation en chaîne (MeSH)</term><term>Réplication virale (MeSH)</term><term>Sélection génétique (MeSH)</term><term>Séquence nucléotidique (MeSH)</term><term>Variation génétique (MeSH)</term><term>Virus de la rougeole (classification)</term><term>Virus de la rougeole (génétique)</term><term>Virus de la rougeole (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Hemagglutinins, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinins, Viral</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>DNA Primers</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Measles virus</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Hémagglutinines virales</term><term>Virus de la rougeole</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Measles virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hémagglutinines virales</term><term>Virus de la rougeole</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la rougeole</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Measles virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Rougeole</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Measles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>B-Lymphocytes</term><term>Base Sequence</term><term>Callithrix</term><term>Cell Line</term><term>Chlorocebus aethiops</term><term>Genetic Variation</term><term>Giant Cells</term><term>Humans</term><term>Phylogeny</term><term>Point Mutation</term><term>Polymerase Chain Reaction</term><term>Selection, Genetic</term><term>Vero Cells</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Amorces ADN</term><term>Animaux</term><term>Callithrix</term><term>Cellules Vero</term><term>Cellules géantes</term><term>Espagne</term><term>Humains</term><term>Lignée cellulaire</term><term>Lymphocytes B</term><term>Mutation ponctuelle</term><term>Phylogenèse</term><term>Réaction de polymérisation en chaîne</term><term>Réplication virale</term><term>Sélection génétique</term><term>Séquence nucléotidique</term><term>Variation génétique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Phylogenetic analysis of the sequence of the H gene of 75 measles virus (MV) strains (32 published and 43 new sequences) was carried out. The lineage groups described from comparison of the nucleotide sequences encoding the C-terminal regions of the N protein of MV were the same as those derived from the H gene sequences in almost all cases. The databases document a number of distinct genotype switches that have occurred in Madrid (Spain). Well-documented is the complete replacement of lineage group C2, the common European genotype at that time, with that of group D3 around the autumn of 1993. No further isolations of group C2 took place in Madrid after this time. The rate of mutation of the H gene sequences of MV genotype D3 circulating in Madrid from 1993 to 1996 was very low (5 x 10(-4) per annum for a given nucleotide position). This is an order of magnitude lower than the rates of mutation observed in the HN genes of human influenza A viruses. The ratio of expressed over silent mutations indicated that the divergence was not driven by immune selection in this gene. Variations in amino acid 117 of the H protein (F or L) may be related to the ability of some strains to haemagglutinate only in the presence of salt. Adaptation of MV to different primate cell types was associated with very small numbers of mutations in the H gene. The changes could not be predicted when virus previously grown in human B cell lines was adapted to monkey Vero cells. In contrast, rodent brain-adapted viruses displayed a lot of amino acid sequence variation from normal MV strains. There was no convincing evidence for recombination between MV genotypes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9010291</PMID><DateCompleted><Year>1997</Year><Month>02</Month><Day>24</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-1317</ISSN><JournalIssue CitedMedium="Print"><Volume>78 ( Pt 1)</Volume><PubDate><Year>1997</Year><Month>Jan</Month></PubDate></JournalIssue><Title>The Journal of general virology</Title><ISOAbbreviation>J. Gen. Virol.</ISOAbbreviation></Journal><ArticleTitle>Sequence divergence of measles virus haemagglutinin during natural evolution and adaptation to cell culture.</ArticleTitle><Pagination><MedlinePgn>97-106</MedlinePgn></Pagination><Abstract><AbstractText>Phylogenetic analysis of the sequence of the H gene of 75 measles virus (MV) strains (32 published and 43 new sequences) was carried out. The lineage groups described from comparison of the nucleotide sequences encoding the C-terminal regions of the N protein of MV were the same as those derived from the H gene sequences in almost all cases. The databases document a number of distinct genotype switches that have occurred in Madrid (Spain). Well-documented is the complete replacement of lineage group C2, the common European genotype at that time, with that of group D3 around the autumn of 1993. No further isolations of group C2 took place in Madrid after this time. The rate of mutation of the H gene sequences of MV genotype D3 circulating in Madrid from 1993 to 1996 was very low (5 x 10(-4) per annum for a given nucleotide position). This is an order of magnitude lower than the rates of mutation observed in the HN genes of human influenza A viruses. The ratio of expressed over silent mutations indicated that the divergence was not driven by immune selection in this gene. Variations in amino acid 117 of the H protein (F or L) may be related to the ability of some strains to haemagglutinate only in the presence of salt. Adaptation of MV to different primate cell types was associated with very small numbers of mutations in the H gene. The changes could not be predicted when virus previously grown in human B cell lines was adapted to monkey Vero cells. In contrast, rodent brain-adapted viruses displayed a lot of amino acid sequence variation from normal MV strains. There was no convincing evidence for recombination between MV genotypes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rima</LastName><ForeName>B K</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>School of Biology and Biochemistry, The Queen's University of Belfast, UK. b.rima@qub.ac.uk</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Earle</LastName><ForeName>J A</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Baczko</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>ter Meulen</LastName><ForeName>V</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Liebert</LastName><ForeName>U G</ForeName><Initials>UG</Initials></Author><Author ValidYN="Y"><LastName>Carstens</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Carabaña</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Caballero</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Celma</LastName><ForeName>M L</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Fernandez-Muñoz</LastName><ForeName>R</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Gen Virol</MedlineTA><NlmUniqueID>0077340</NlmUniqueID><ISSNLinking>0022-1317</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017931">DNA Primers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006389">Hemagglutinins, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001402" MajorTopicYN="N">B-Lymphocytes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002144" MajorTopicYN="N">Callithrix</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017931" MajorTopicYN="N">DNA Primers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="Y">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015726" MajorTopicYN="N">Giant Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006389" MajorTopicYN="N">Hemagglutinins, Viral</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008457" MajorTopicYN="N">Measles</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008459" MajorTopicYN="N">Measles virus</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="Y">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017354" MajorTopicYN="Y">Point Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012641" MajorTopicYN="N">Selection, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1997</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1997</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1997</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9010291</ArticleId><ArticleId IdType="doi">10.1099/0022-1317-78-1-97</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Baczko, K" sort="Baczko, K" uniqKey="Baczko K" first="K" last="Baczko">K. Baczko</name><name sortKey="Caballero, M" sort="Caballero, M" uniqKey="Caballero M" first="M" last="Caballero">M. Caballero</name><name sortKey="Caraba A, J" sort="Caraba A, J" uniqKey="Caraba A J" first="J" last="Caraba A">J. Caraba A</name><name sortKey="Carstens, C" sort="Carstens, C" uniqKey="Carstens C" first="C" last="Carstens">C. Carstens</name><name sortKey="Celma, M L" sort="Celma, M L" uniqKey="Celma M" first="M L" last="Celma">M L Celma</name><name sortKey="Earle, J A" sort="Earle, J A" uniqKey="Earle J" first="J A" last="Earle">J A Earle</name><name sortKey="Fernandez Mu Oz, R" sort="Fernandez Mu Oz, R" uniqKey="Fernandez Mu Oz R" first="R" last="Fernandez-Mu Oz">R. Fernandez-Mu Oz</name><name sortKey="Liebert, U G" sort="Liebert, U G" uniqKey="Liebert U" first="U G" last="Liebert">U G Liebert</name><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V" last="Ter Meulen">V. Ter Meulen</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Rima, B K" sort="Rima, B K" uniqKey="Rima B" first="B K" last="Rima">B K Rima</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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